Endocrine Abstracts

Case history: We present a case of a 34-year-old male diagnosed with bilateral gynecomastia referred to the endocrine clinic. Notable background of left cryptorchidism with orchidopexy at the age of 15, delayed puberty, chronic testicular pain and atopic dermatitis. On examination he had short stature, hypertelorism, low set ears, broad short hands, brachydactyly and clinodactyly of 5th fingers. There was no evidence of cleft lip/palate, teeth abnormalities or inguinal/abdomin...

Introduction: Hyponatremia is a common electrolyte disorder in clinical practice. We did a retrospective analysis of 100 patients admitted between Jan 2019 to June 2019 with moderate hyponatremia (Na-125-129 mmol/l) to see if there was a difference in management and outcome of the patients who were formally coded as hyponatremia and those who were not coded as such.Results: Mean age was 74 years in the coded group (n...

A 32-years-old lady was admitted with raised calcium. She had palpitation, sweating, 3 stones weight loss and neck swelling. She was diagnosed with Graves’ disease 5 months ago. Her mother had history of thyroid disease but no family history of hypercalcaemia. She had a small goitre and lid lag on examination. On admission, adjusted calcium was 3.04 mmol/l. PTH was < 0.5 pmol/l. Phosphate, vitamin-D, kidney functions, cortisol, myeloma screen and ACE levels ...

Introduction: Growth hormone secretogogues (GHS) are popular among body building communities as muscle bulking agents. We present an interesting case of new onset diabetes induced by a combination of GHS and selective androgen receptor modulators (SARMs).Case report: A 34-years body builder was referred by his GP due to a 3-week history of polyuria, polydipsia and fatigue. He had recently used one cycle of a combination tablet which contained Ibutamoren ...

Background and aim: The Department of Health and NHS Plan both recognise that sending patients copies of clinic correspondence can help inform and empower them. At St Helens and Knowsley Teaching Hospitals NHS Trust, Endocrinology Clinic we routinely provide patients with a copy of the clinic correspondence sent to their General Practitioner (GP), unless patients specifically opt out. Our aim was to evaluate patients’ views on receiving such copy correspondence following ...

Thyroid hormone resistance is a rare but recognised cause of clinical hypothyroidism. We explain a case of clinical hypothyroidism that was associated with thyroid hormone resistance.A 48-year Caucasian female with no known personal or family endocrine history was referred with a 12-month-history of weight gain and increased tiredness. Past history included depression and osteoarthritis, with regular medications being NSAIDs and amitryptiline. There was ...

High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained fro...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Introduction: T2DM is one of the main causes of morbidity and mortality in the UK. Epigenetic mechanisms impact gene expression and could predispose individuals to a particular metabolic phenotype. We investigated association of LINE-1 methylation (a surrogate of global DNA methylation) with cardiometabolic parameters in a longitudinal cohort of T2DM patients.Methods: Global LINE-1 DNA methylation in blood-derived DNA samples from 795 (men 60%, women 40%...

Section 1: Case history: A 61-year-old lady was referred by her GP to our endocrine clinic with abnormal thyroid function tests (TFTs) incidentally identified in routine blood tests. She had no symptoms suggestive of thyrotoxicosis apart from occasional palpitations when using inhalers for asthma. She had no family history of endocrine significance. She was on salbutamol, salmeterol, fluticasone inhalers and laxatives. Physical examination was unremarkable with no goitre. ...